Koch's postulates, microbial dysbiosis and inflammatory bowel disease

Dysbiosis in inflammatory bowel disease.

Abundant data have incriminated intestinal bacteria in the initiation and amplification stages of inflammatory bowel diseases. However, the precise role of intestinal bacteria remains elusive. One theory has suggested a breakdown in the balance between putative species of "protective" versus "harmful" intestinal bacteria--this concept has been termed "dysbiosis". Arguments in support of this co...

Inflammatory bowel disease: treatment postulates and future prospects.

Identification of Unknown Turfgrass Pathogens: Kochs Postulates

History In 1876, a country doctor in Germany by the name of Robert Koch developed the first conclusive empirical evidence that a particular microbe causes a particular disease. Although he was working on anthrax, a deadly disease of warm-blooded animals (caused by the bacterium Bacillus anthracis), the procedures he laid out for determining the pathogenicity of a microorganism (in other words, ...

Dysbiosis in inflammatory bowel disease: a role for bacteriophages?

Intestinal bacteria have been implicated in the initiation and amplification of inflammatory bowel disease (IBD). The dysbiosis theory, reviewed by Tamboli et al (Gut 2004;53:1), is that an imbalance between putative ‘‘harmful’’ versus ‘‘protective’’ bacterial species may promote chronic intestinal inflammation. Although several studies published so far support this hypothesis, the most vexing ...

Neonatal Presentation of Unremitting Inflammatory Bowel Disease

Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian fe...